Novel tumor necrosis factor receptor homolog and nucleic...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319236

The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptides molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

L'invention concerne de nouveaux polypeptides présentant une homologie vis-à-vis des éléments de la famille des récepteurs du facteur nécrosant des tumeurs ainsi que des molécules codant ces polypeptides. L'invention concerne également des vecteurs et des cellules hôtes renfermant ces séquences d'acides nucléiques, des molécules polypeptidiques chimériques contenant les polypeptides de l'invention condensées à des séquences polypeptidiques hétérologues, des anticorps se liant aux polypeptides de l'invention, ainsi que des procédés de production des polypeptides selon l'invention.

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