C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/179, 260/292
C07D 295/00 (2006.01) A61K 31/135 (2006.01) A61K 31/395 (2006.01) C07C 211/42 (2006.01) C07D 211/08 (2006.01) C07D 241/04 (2006.01) C07D 295/03 (2006.01) C07D 295/033 (2006.01) C07D 295/088 (2006.01)
Patent
CA 2039398
Case 2606 PROPANOBICYCLIC AMINE DERIVATIVES FOR CNS DISORDERS ABSTRACT Certain propanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula Image wherein each of R1, R2, R3, R4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R3 and R4 may be taken together to form oxo; wherein each of R9, R10, R11, R12, R13 and R14 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, cycloalkylalkyl, alkoxyalkyl, phenalkyl and phenyl; wherein G within the nitrogen-containing cyclohetero moiety is selected from Image and Image ; wherein R15 is selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenalkyl, alkoxyalkyl and hydroxyalkyl; wherein each of R16 and R17 is independently selected from hydrido, hydroxy, alkyl, phenalkyl, phenyl, alkoxy, fluoroalkyl and fluoro: wherein m is one or two; wherein p is a number selected from zero through four, inclusive; wherein each of q and r is a number independently selected from one through three, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive; with the further proviso that the nitrogen-containing cyclohetero moiety must be attached at one position selected from R3, R4, ring-position two, ring-position three and ring-position four; or the pharmaceutically-acceptable salts thereof.
Cheng Brian K.
Gray Nancy M.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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