Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 491/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2467726

The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention se rapporte à des composés de furanopyrimidinone utilisés pour : traiter des maladies cellulaires proliférantes ; traiter des troubles associés à l'activité de la kinésine KSP ; et inhiber l'activité de la kinésine KSP. L'invention se rapporte également à des compositions comprenant ces composés, ainsi qu'à leurs procédés d'utilisation dans le traitement du cancer chez des mammifères.

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