High affinity nucleic acid ligands to lectins

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2223275

This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.

La présente invention décrit des ligands oligonucléotidiques à haute affinité pour les lectines, spécifiquement des ligands d'acide nucléique possédant la capacité de se lier aux lectines, à l'agglutinine de germe de blé, à la L-sélectine, E-sélectine et P-sélectine. Elle décrit également des procédés pour obtenir ces ligands.

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