Process for the preparation of a macrocycle

Details Process for the preparation of a macrocycle Process for the preparation of a macrocycle

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2732091

The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula (XXII) wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.

La présente invention porte sur un nouveau procédé pour la préparation de composés inhibiteurs de la protéase de VHC macrocyclique de la formule (XXII), dans laquelle R1 est un groupe protecteur d'amino et X est un halogène au moyen d'une approche de métathèse de fermeture de cycle.

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