Genetic modification of targeted regions of the cardiac...

Details Genetic modification of targeted regions of the cardiac... Genetic modification of targeted regions of the cardiac...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2523575

Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.

L'invention concerne des procédés et des systèmes de prévention ou de traitement d'un dysfunctionnement cardiaque, en particulier un dysfunctionnement de stimulation cardiaque, par modification génétique du système de conduction cardiaque. Dans un mode de réalisation, on décrit un procédé de modification génétique des cellules, qui consiste à transmettre aux cellules une ou plusieurs séquences de codage dans une construction génétique pouvant modifier l'expression des canaux ioniques des cellules.

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