Stable controlled release pharmaceutical compositions...

Details Stable controlled release pharmaceutical compositions... Stable controlled release pharmaceutical compositions...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/28 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 9/44 (2006.01) A61K 31/22 (2006.01)

Patent

CA 2449998

Stabilized sustained release pharmaceutical preparations containing a drug which is sensitive to a low pH environment, such as pravastatin are disclosed in which pravastatin degradation is prevented with a buffering agent. The basic excipient enhances storage stability.

L'invention concerne des compositions pharmaceutiques, à libération contrôlée, stabilisées contenant un principe actif sensible à un environnement à faible pH, par exemple de la pravastatine, ainsi qu'un agent tampon servant à empêcher la dégradation de la pravastatine. L'excipient basique améliore la stabilité au stockage.

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