C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2288962
In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
La présente invention concerne des anticorps monoclonaux entièrement humains contre le récepteur du facteur de croissance épidermique humain (EGF-r). Elle concerne également des séquences nucléotidiques codant et des séquences aminoacides comprenant des molécules d'immunoglobuline à chaînes lourdes et légères, notamment des séquences correspondant à des séquences de chaînes lourdes et légères contiguës, allant des régions déterminantes complémentaires CDR1 à CDR3. L'invention concerne d'autre part des hybridomes exprimant ces molécules d'immunoglobuline et ces anticorps monoclonaux.
Gallo Michael
Jakobovits Aya
Jia Xiao-Chi
Yang Xiao-Dong
Abgenix Inc.
Amgen Fremont Inc.
Gowling Lafleur Henderson Llp
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