Use of protein kinase c inhibitors to enhance the clinical...

Details Use of protein kinase c inhibitors to enhance the clinical... Use of protein kinase c inhibitors to enhance the clinical...

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/70 (2006.01) A61K 33/24 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2253263

A method for treating neoplasms is disclosed, particularly using the .beta.- isozyme selective PKC inhibitor, (S)-3,4-[N,N'-1,1'-((2''-ethoxy)-3'''(O)-4'''- (N,N-dimethylamino)-butane)-bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione or one of its salts, such PKC inhibitors enhance the clinical efficacy of oncolytic agents and radiation therapy.

Méthode de traitement des néoplasmes utilisant en particulier l'inhibiteur sélectif de l'isozyme .beta. de la protéine Kinase C (PKC): (S)-3,4-[N,N'-1,1'-((2''-éthoxy)-3'''(0)-4'''-(N,N-diméthylamino)-butane)-bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione ou un sel de ce dernier. Ces inhibiteurs de PKC augmentent l'efficacité clinique des agents oncolytiques et de la radiothérapie.

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