A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01)
Patent
CA 2310141
The invention concerns the use for making medicines with waking effect in conditions of disorders affecting wakefulness related to morphine treatment, of sulphinyl benzhydryl compounds of formula (I) in which: each of the cycles is substituted by one or several groups F, Cl, Br, CF¿3?, NO¿2?, NH¿2?, C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy, methylenedioxy; R is -OH, H, C¿1?-C¿4? alkyl, C¿1?-C¿4? hydroxyalkyl, or R¿1?R¿2?N-Y-, where Y is a hydrocarbon radical in C¿1?-C¿4? with linear or branched chain; n is a whole number equal to 1, 2 or 3; and their additive salts when R comprises a basic radical. Said medicines enable to reduce sleepiness in patients without affecting the antalgic effect of morphine.
L'invention concerne l'utilisation, pour la fabrication de médicaments à effet d'éveil dans des situations de troubles de la vigilance liés à un traitement morphinique, des composés de benzhydryl sulfinyle de formule (I), dans laquelle, chacun des cycles est substitué par un ou plusieurs groupes F, Cl, Br, CF3, NO2, NH2, alkyle en C1-C4, alcoxy en C1-C4, méthylènedioxy; R est -OH, H, alkyle en C1-C4, hydroxyalkyle en C1-C4, ou R1R2N-Y-, où Y est un reste hydrocarboné en C1-C4 à chaîne linéaire ou ramifiée; n est un entier égal à 1, 2 ou 3; et leurs sels d'addition lorsque R comporte un reste basique. Ces médicaments permettent de réduire l'état de somnolence des patients sans affecter l'effet antalgique de la morphine.
Esteve Marc
Gertner Jacques
Institut Curie
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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