Antisense modulation of c-reactive protein expression

Details Antisense modulation of c-reactive protein expression Antisense modulation of c-reactive protein expression

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2454791

Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.

L'invention concerne des composés antisens, des compositions et des procédés permettant de moduler l'expression de la protéine réactive C. Les compositions comprennent des composés antisens, en particulier des oligonucléotides antisens ciblés sur des acides nucléiques codant pour la protéine réactive C. L'invention concerne aussi des méthodes d'utilisation de ces composés afin de moduler l'expression de la protéine réactive C et de traitement de maladies associées à l'expression de la protéine réactive C.

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