Gene encoding protein b

Details Gene encoding protein b Gene encoding protein b

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 8/64 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) A61Q 19/00 (2006.01) C07K 14/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2398093

An objective of this invention is to identify and provide a gene encoding medaka protein B. An additional objective of the present invention is to provide human and murine homologues of the gene. To achieve the above mentioned objectives, the inventors performed positional cloning on the B gene. The gene encoding medaka protein B was successfully isolated, and the present invention has come to completion. Accordingly, in accordance with the invention, there are provided a nucleic acid encoding medaka protein B and those encoding homologues thereof. According to another aspect of the invention, there are provided a nucleic acid listed in Seq. No. 1 that encodes medaka protein B and a nucleic acid listed in Seq. No. 3 that encodes mouse protein B/AIM-1. According to the invention, there is provided a method of suppressing melanin production characterized in that expression of the gene encoding protein B is suppressed.

Grâce au clonage positionnel du gène B, on peut isoler avec succès un gène codant la protéine B du cyprinodontidé. Plus particulièrement, l'invention porte sur des acides nucléiques codant la protéine B du cyprinodontidé et son homologue. Elle a également trait à un acide nucléique codant la protéine B du cyprinodontidé représentée par SEQ ID NO :1 et à un autre acide nucléique codant la protéine B/AIM-1 de la souris représentée par SEQ ID NO :3. Par ailleurs, l'invention porte sur un procédé d'inhibition de mélanogénèse qui se caractérise par l'inhibition d'un gène codant la protéine B.

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