Peptides for activation and inhibition of delta pkc

Details Peptides for activation and inhibition of delta pkc Peptides for activation and inhibition of delta pkc

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 5/103 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2434643

Peptides able to inhibit or activate the translocation or function of öPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for öPKC-selective agonists and antagonists.

L'invention concerne l'identification de peptides capable d'inhiber ou d'activer la translocation ou la fonction de .delta.PKC. L'invention décrit l'administration des peptides afin de protéger ou améliorer des lésions cellulaires dues à l'ischémie. L'invention décrit aussi des méthodes thérapeutiques destinées à réduire les lésions cellulaires ou à améliorer la condition de ces lésions dues à l'ischémie, ainsi que des méthodes de criblage de composés tests destinés aux agonistes et antagonistes sélectifs .delta.PKC.

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