Method and composition for modulating amyloidosis

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/00 (2006.01) A61K 31/138 (2006.01) A61K 31/277 (2006.01) A61K 31/352 (2006.01) A61K 31/4045 (2006.01) A61K 31/407 (2006.01) A61K 31/46 (2006.01) A61K 31/473 (2006.01) A61K 31/475 (2006.01) A61K 31/49 (2006.01) A61K 31/5415 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2285948

Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that modulation of amyloid deposition occurs. Methods also include administering an effective amount of at least one ABC transporter blocker, or a pharmaceutically acceptable salt thereof, to a subject such that a disease state associated with amyloidosis is treated. Packaged pharmaceutical compositions for treating amyloidosis are described. The package includes a container for holding an effective amount of a pharmaceutical composition and instructions for using the pharmaceutical composition for treatment of amyloidosis. The pharmaceutical composition includes at least one ABC blocker for modulating amyloid deposition in a subject. Methods for identifying agent which modulate amyloid deposition in a subject are also described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to an organism, such that modulation of amyloid deposition occurs.

L'invention concerne des méthodes permettant de moduler le dépôt amyloïde chez un sujet. On administre au sujet une dose efficace d'au moins un inhibiteur de transporteur de cassette de liaison d'ATP (ABC), de manière à moduler le dépôt amyloïde. Ces méthodes consistent également à administrer au sujet une dose efficace d'au moins un inhibiteur de transporteur d'ABC ou d'un de ses sels pharmaceutiquement acceptables, de manière à traiter un état pathologique associé à l'amyloïdose. L'invention concerne aussi des compositions pharmaceutiques conditionnées permettant de traiter l'amyloïdose. Le conditionnement comprend un contenant destiné à renfermer une dose efficace d'une composition pharmaceutique ainsi que les instructions d'utilisation de ladite composition pour le traitement de l'amyloïdose. La composition pharmaceutique renferme au moins un inhibiteur d'ABC pour moduler le dépôt amyloïde chez un sujet. L'invention a en outre pour objet des procédés d'identification d'agents modulant le dépôt amyloïde chez un sujet. On administre à un organisme une dose efficace d'au moins un inhibiteur de transporteur d'ABC de manière à moduler le dépôt amyloïde.

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