Dna ligase iv

Details Dna ligase iv Dna ligase iv

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2203651

A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.

Cette invention a pour objet un polypeptide, l'ADN-ligase III humaine et l'ADN (ARN) codant ce polypeptide, ainsi qu'une procédure de production dudit polypeptide au moyen de techniques de recombinaison; des procédés d'utilisaton du polypeptide par thérapie génique pour traiter les troubles associés à un défaut dans l'ADN-ligase III; des antagonistes dirigés contre lesdits polypeptides et leur utilisation comme agents thérapeutiques pour détruire des cellules indésirables; et enfin des techniques de diagnostic qui permettent de détecter des gènes mutants d'ADN-ligase III.

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