Polymeric gel system for the controlled delivery of codrugs

Details Polymeric gel system for the controlled delivery of codrugs Polymeric gel system for the controlled delivery of codrugs

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 45/06 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61K 47/48 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2472188

Implantable, injectable, insertable, or otherwise administrable compositions that form hydrogels when implanted, injected, inserted, or administered into or onto living tissues comprise a pharmaceutically effective compound wherein the pharmaceutically effective compound is a codrug, or pharmaceutically acceptable salt or prodrug thereof in admixture with a hydrogel-forming compound. The pharmaceutically effective compound may be any compound that is soluble in bodily fluids, or that forms bodily fluid-soluble adducts when exposed to bodily fluids. Exemplary compounds include analgesic, anti- inflammatory and antibiotic compounds. The hydrogel-forming compound is a biologically tolerated substance that forms a hydrogel upon exposure to bodily fluids, such as the interstitial fluid surrounding or within a joint.

L'invention concerne des compositions implantables, injectables, insérables ou administrables formant des hydrogels une fois implantées, injectées, insérées ou administrées dans ou sur des tissus vivants, qui renferment un composé pharmaceutiquement efficace, ledit composé efficace étant un médicament combiné, ou un sel ou un promédicament pharmaceutiquement acceptable de celui-ci dans un adjuvant avec un composé formant un hydrogel. Le composé pharmaceutiquement efficace peut être un composé quelconque susceptible de se dissoudre dans des liquides organiques, ou de former des produits d'addition solubles dans des liquides organiques lorsqu'ils sont exposés à de tels liquides. Il peut s'agir, par exemple, de composés analgésiques, anti-inflammatoires et antibiotiques. Le composé formant un hydrogel est une matière biologiquement tolérée formant un hydrogel lorsqu'elle est exposée à des liquides organiques, tels que le liquide interstitiel enveloppant une articulation ou se trouvant à l'intérieur de celle-ci.

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