C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2286204
The present invention provides a method for the treatment or prophylaxis of benign prostatic hyperplasia or prostatic cancer in a patient in need of such treatment comprising administering a selective estrogen receptor modulating compound of formula (I), in which R1 and R2 are independently hydroxy and alkoxy of one to four carbon atoms; and R3 and R4 are independently methyl or ethyl, or R3 and R4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.
Cette invention se rapporte à un procédé pour le traitement ou la prophylaxie de l'hyperplasie prostatique bénigne ou du cancer de la prostate chez un patient nécessitant un tel traitement, ce procédé consistant à lui administrer un composé à effet de modulation sélective des récepteurs d'oestrogènes, représenté par la formule (I), où R?1¿ et R?2¿ représentent séparément hydroxy et alcoxy ayant 1 à 4 atomes de carbone; et R?3¿ et R?4¿ représentent séparément méthyle ou éthyle, ou R?3¿ et R¿4? forment, avec l'atome d'azote auquel ils sont liés, un cycle pyrrolidino, méthylpyrrolidino, diméthylpyrrolidino, pipéridino, morpholino ou hexaméthylène-imino.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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