Prophylactic/therapeutic agents for atherosclerosis

A - Human Necessities – 61 – K

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Details

A61K 31/34 (2006.01) A61K 31/085 (2006.01) A61K 31/343 (2006.01) A61K 31/35 (2006.01) C07D 307/79 (2006.01) C07D 493/10 (2006.01)

Patent

CA 2289676

Preventives/remedies for arteriosclerosis containing as the active ingredient compounds represented by general formula (1), potential optically active isomers thereof, or pharmaceutically acceptable salts of the same. In said formula (1) R1 represents hydrogen or acyl; R2 represents lower alkyl; R3 represents hydrogen or lower alkyl; and R4, R5 and R6 represent each hydrogen, alkyl, alkenyl, alkynyl or aryl, or R2 and R4 may form together with the oxygen atom a furan or dihydrofuran ring, and R5 and R6 may form together cycloalkyl on which at least one methylene is optionally substituted by oxygen, sulfur or alkylated nitrogen to give a heterocycle.

Agents prophylactiques et thérapeutiques contre l'artériosclérose contenant, en tant qu'ingrédient actif, des composés représentés par la formule générale suivante (1), leurs isomères potentiels présentant une efficacité sur le plan optique ou certains de leurs sels acceptables sur le plan pharmaceutique: (1) dans laquelle R?1¿ représente hydrogène ou acyle; R?2¿ représente alkyle inférieur; R?3¿ représente hydrogène ou alkyle inférieur; R?4¿, R?5¿ et R?6¿ représentent chacun hydrogène, alkyle, alkényle, alkynyle ou aryle, ou R?2¿ et R?4¿ peuvent constituer avec l'atome d'oxygène un noyau furane ou dihydrofurane, et R?5¿ et R?6¿ peuvent constituer ensemble cycloalkyle sur lequel au moins un méthylène est éventuellement substitué par oxygène, soufre ou azote alkylé afin de produire un composé hétérocyclique.

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