Methods for alzheimer's disease treatment and cognitive...

Details Methods for alzheimer's disease treatment and cognitive... Methods for alzheimer's disease treatment and cognitive...

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61K 31/00 (2006.01) A61K 31/335 (2006.01) A61K 31/35 (2006.01) A61K 31/7048 (2006.01)

Patent

CA 2477973

The present invention relates to compositions and methods to modulate .alpha.- secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatment thereof through increased sAPP production. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are compounds preferred for use with the present composition. The present invention also provides methods for increasing the generation of non- amyloidogenic soluble APP comprising the activation of protein kinase C (PKC) by administering an effective amount of PKC activator(s).

L'invention concerne des compositions et des procédés de modulation de l'.alpha.-secrétase et/ou d'amélioration de la capacité cognitive. L'invention concerne également la capacité cognitive améliorée/accrue chez des individus malades, tels que des patients souffrant de la maladie d'Alzheimer, ainsi qu'un traitement de ceux-ci au moyen d'une production accrue de protéines précurseurs amyloïdes solubles (sAPP). Des lactones macrocycliques (notamment de la classe de la bryostatine et la classe de la néristatine) sont des composés préférés à utiliser avec la composition selon l'invention. L'invention concerne enfin des procédés permettant d'augmenter la génération de protéines précurseurs amyloïdes (APP) non amyloïdogéniques solubles consistant à activer une protéine kinase C (PKC) par administration d'une quantité efficace d'un ou de plusieurs activateurs de PKC.

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