Humanized immunoglobulin loci

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/46 (2006.01)

Patent

CA 2532117

The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations.

L'invention se rapporte à des procédés et des moyens de production d'anticorps à partir d'animaux non humains transgéniques. Cette invention porte notamment sur des constructions de chaînes lourdes et légères d'immunoglobuline, sur des vecteurs de recombinaison et des vecteurs transgéniques utiles dans la fabrication d'animaux non humains transgéniques exprimant des anticorps humanisés, sur des animaux transgéniques, et sur des préparations d'immunoglobuline humanisées.

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