C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2246230
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (-O-CH2CH2OCH3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.
L'invention concerne des compositions et des procédés permettant de moduler l'expression de la protéine kinase C. On décrit des oligonucléotides qui ciblent des acides nucléiques codant la PKC et contiennent une modification de méthoxyéthoxy (-O-CH¿2?CH¿2?OCH¿3?) en position 2' d'au moins un nucléotide. On décrit aussi des procédés permettant d'inhiber l'expression de la PKC et des procédés de traitement d'affections associées à l'expression de la PKC à l'aide des oligonucléotides décrits.
Altmann Karl-Heinz
Dean Nicholas M.
Martin Pierre
Isis Pharmaceuticals Inc.
Novartis Ag
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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