A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 9/00 (2006.01) A61K 38/19 (2006.01) A61K 38/28 (2006.01) A61K 39/39 (2006.01)
Patent
CA 2360643
The invention deals with the transport of preferably large molecules across nasal mucosa by means of specially designed, highly adaptable carriers loaded with said molecules. One of the purposes of making such formulations is to achieve non-invasive systemic delivery of therapeutic polypeptides, proteins and other macromolecules; the other intent is to overcome circumstantially the blood-brain barrier by exploiting the nasal cavity to enter the body and then to get access to the brain. A third intent is to achieve successful protective or tolerogenic immunisation via nasal antigen or allergen administration.
L'invention concerne le transport de molécules de préférence grandes à travers la muqueuse nasale au moyen de porteurs hautement adaptables, conçus spécifiquement et chargés de ces molécules. L'un des objets de telles préparations est d'obtenir une diffusion systémique non invasive de polypeptides, protéines et autres macromolécules thérapeutiques. L'invention vise également à surmonter accessoirement la barrière hémato-encéphalique en exploitant la cavité nasale pour entrer dans le corps, puis accéder au cerveau. L'invention vise en outre à atteindre une immunisation tolérogénique ou protectrice réussie par administration nasale d'antigène ou d'allergène.
Cevc Gregor
Chopra Amla
Stieber Juliane
Goudreau Gage Dubuc
Idea Ag
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