Treatment of cataract with 15-keto-prostaglandin compounds

Details Treatment of cataract with 15-keto-prostaglandin compounds Treatment of cataract with 15-keto-prostaglandin compounds

A - Human Necessities

61

K

167/205, 260/235

A61K 31/557 (2006.01) C07C 405/00 (2006.01)

Patent

CA 2039420

A pharmaceutical composition for treatment of cataract comprising a 15-ketoprostaglandin compound in association with a pharmaceutically acceptable carrier, diluent or excipient, of the general formula: Image (I) wherein L and M are hydrogen atom, hydroxy, lower alkyl, hydroxy(lower)alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two doubl.e bonds, Q1 and Q2 are hydrogen atom, halogen atom or lower alkyl, D is -CH2-CH2-, -CH=CH-, -CC- or -CO-CH2-, E is -CH2-CH2- or -CH=CH-, W is -CH2-CH2-CH2-, -CH=CH-CH2 or -CH2-CH=CH-, Ra is hydrogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl(lower)alkyl or monocyclic aroyl(lower)alkyl, Rb is single bond or lower alkylene, Rc is lower alkyl which is unsubstituted or substituted with halogen, lower cycloalkyl which is unsubstituted or substituted with lower alkyl, monocyclic aryl which is unsubstituted or substituted with halogen or halo(lower)alkyl, or monocyclic aryloxy which is unsubstituted or substituted with halogen or halo(lower)alkyl, or a pharmaceutically acceptable salt when Ra is hydrogen atom.

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