Pentafluorosulfanyl benzoylguanidines, method for their...

Details Pentafluorosulfanyl benzoylguanidines, method for their... Pentafluorosulfanyl benzoylguanidines, method for their...

C - Chemistry, Metallurgy

07

C

C07C 381/00 (2006.01) A61K 31/166 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2551057

The invention relates to pentafluorosulfanyl benzoylguanidines of formula (I), in which R1 to R4 are defined as cited in the claims. Said substances are suitable for use as anti-arrhythmic medicaments comprising cardio-protective components for the prophylaxis and treatment of infarcts, in addition to the treatment of angina pectoris. They also preventatively inhibit the pathophysiological events that occur during ischaemically induced traumas, in particular during the triggering of ischaemically induced cardiac arrhythmia.

L'invention concerne des pentafluorsulfanyl-benzoylguanidines de formule (I), dans laquelle R1 à R4 ont les significations indiquées dans les revendications, ces composés servant, par exemple, de médicaments contre arythmie cardiaque, comprenant des composantes de protection cardiaque, pour prévenir ou traiter l'infarctus et traiter l'angine de poitrine. Elles inhibent également de façon préventive les phénomènes patho-physiologiques en cas de dommages induits par l'ischémie, notamment lors du déclenchement d'arythmies cardiaques induites par l'ischémie.

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