Use of phospholipids in peritoneal dialysis

Details Use of phospholipids in peritoneal dialysis Use of phospholipids in peritoneal dialysis

A - Human Necessities

61

K

A61K 31/685 (2006.01) A61K 31/661 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2473081

The efficiency of ultrafiltration in continuous ambulatory peritoneal dialysis (CAPD) is improved by administering a composition comprising at least one surface active phospholipid (SAPL) in powder form, especially as a mixture of phosphatidyl choline and phosphatidyl glycerol, into the peritoneal cavity before commencing CAPD or between CAPD sessions. The SAPL composition may be introduced during surgery to prepare a patient for CAPD and/or subsequently through the incision for the CAPD catheter, or through the catheter itself, between CAPD sessions when one batch of dialysis fluid has been removed and before a fresh batch is supplied.

L'efficacité de l'ultrafiltration dans la dialyse péritonéale ambulatoire continue (CAPD) est améliorée par administration d'une composition contenant au moins un phospholide tensioactif (SAPL) sous forme de poudre, notamment sous forme d'un mélange de phosphatidyl choline et de phosphatidyl glycérol, dans la cavité péritonéale avant le début de la CAPD ou entre les sessions de CAPD. La composition SAPL peut être introduite au cours de l'intervention afin de préparer un patient à la CAPD et/ou par la suite, par incision pour introduire le cathéter CAPD, ou à travers le cathéter lui-même, entre les sessions de CAPD lorsqu'un lot de fluide de dialyse a été ôté et avant qu'un nouveau lot ne soit fourni.

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