Complement factor h-derived short consensus repeat-antibody...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2687395

The present invention relates to a complement activating construct comprising a complement factor H-derived short consensus repeat (fH-derived SCR) and a binding molecule which specifically recognizes a pathogen. More specifically, the fH-derived SCR is selected from the group consisting of SCR7, SCR9, SCR13, SCRl 8-20 and artificial SCR (aSCR). Furthermore, an in vivo method for screening complement-based approaches for the treatment of the prevention, treatment or amelioration of an infection with a pathogen or a pathological condition associated with an infection with a pathogen is described.

La présente invention porte sur un anticorps de synthèse d'activation du complément comportant une séquence SCR dérivée du facteur H du complément (SCR dérivée de fH) et une molécule de liaison qui reconnaît spécifiquement un pathogène. Plus précisément, la SCR dérivée de fH est sélectionnée dans le groupe constitué par SCR7, SCR9, SCR13, SCR18-20 et SCR artificielle (aSCR). Un procédé in vivo de criblage d'approches à base du complément pour le traitement ou la prévention, le traitement ou l'amélioration d'une infection par un pathogène ou un état pathologique associé à une infection par un pathogène est également décrit.

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