Recombinant glycosyltransferase fusion proteins

Details Recombinant glycosyltransferase fusion proteins Recombinant glycosyltransferase fusion proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 19/00 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2485102

This invention provides recombinant glycosyltransferase fusion proteins having a desired level of expression and enzymatic activity (for example, acceptor substrate specificity or catalytic activity). The fusion proteins of the invention have a functional domain of a first glycosyltransferase joined, directly or through a peptide linker, to a subsequence of a functional domain of a second glycosyltransferase. Nucleic acids that encode the fusion proteins are also provided, as are host cells for expressing the fusion proteins and methods of making and using the fusion proteins of the invention.

La présente invention concerne des protéines de fusion recombinantes de glycosyltransférase présentant un niveau désiré d'expression et d'activité enzymatique (par exemple, spécificité de substrat accepteur ou activité catalytique). Les protéines de fusion de l'invention portent un domaine fonctionnel d'une première glycosyltransférase reliée, directement ou via un peptide de liaison, à une sous-séquence d'un domaine fonctionnel d'une deuxième glycosyltransférase. L'invention concerne également les acides nucléiques qui codent ces protéines de fusion, des cellules hôtes pour exprimer les protéines de fusion, et des procédés pour la réalisation et l'utilisation des protéines de fusion de l'invention.

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