Conjugated suramin amino compounds for medical conditions

A - Human Necessities – 61 – K

Patent

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A61K 47/18 (2006.01) A61K 31/185 (2006.01)

Patent

CA 2733228

A modification of pharmacokinetics of suramin by use of amino compounds in modification of lipophilicity and protein binding characteristics for tackling the physico-chemical properties of suramin that gives it poor distribution in the body; formulating the resulting product in a form that leads to targeting body fluids like the lymphatic system when administered in a specific way; and determining the route of administration that maximizes targeting with a view to reducing the dosage so as to limit toxicity, hence increase tolerance by patient.

L'invention porte sur la modification de la pharmacocinétique de la suramine par l'utilisation de composés amino dans la modification de la lipophilicité et des caractéristiques de liaison à une protéine pour s'attaquer aux propriétés physico-chimiques de la suramine qui lui donnent une répartition médiocre dans le corps ; la formulation du produit résultant dans une forme qui conduit au ciblage de fluides corporels tels que le système lymphatique lorsqu'il est administré d'une façon spécifiée ; et la détermination de la voie d'administration qui rend maximal le ciblage dans le but de réduire le dosage de façon à limiter la toxicité, par conséquent augmenter la tolérance par un patient.

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