Dipeptide nitrile cathepsin k inhibitors

Details Dipeptide nitrile cathepsin k inhibitors Dipeptide nitrile cathepsin k inhibitors

C - Chemistry, Metallurgy

07

D

C07D 295/14 (2006.01) A61K 31/451 (2006.01) A61K 31/495 (2006.01) C07D 211/34 (2006.01) C07D 295/155 (2006.01)

Patent

CA 2396158

The invention provides a compound of formula II, or a pharmaceutically acceptable salt thereof: (see formula II) The compounds of the invention may be used in the prophylactic or therapeutic treatment of a disease or medical condition which involves an elevated level of cathepsin K, wherein the disease or medical condition is hypercalcemia of malignancy, excessive bone loss, excessive cartilage degradation or excessive matrix degradation. The disease or condition may also be osteoporosis, rheumatoid arthritis, osteoarthritis, gingival disease, Paget's disease or hypercalcemia of malignancy.

L'invention concerne des inhibiteurs de cathépsine nitrile dipeptide K correspondant à la formule (I), et leurs sels ou esters acceptables sur le plan pharmaceutique. Dans cette formule, R1 et R2 représentent indépendamment un atome d'hydrogène ou un groupe alkyle inférieur en C1-C7, ou R1 et R2 et l'atome de carbone auquel ils sont liés forme une chaîne cycloalkyle en C3-C8, et Het représente un substitut hétérocyclique contenant de l'azote substitué, utile dans le traitement thérapeutique et prophylactique d'une maladie ou d'un état pathologique dans lequel la cathépsine K est impliquée.

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