Molecules with antibody combining sites that exhibit...

Details Molecules with antibody combining sites that exhibit... Molecules with antibody combining sites that exhibit...

C - Chemistry, Metallurgy

12

P

530/3.1, 195/1.1

C12P 21/08 (2006.01) C07F 9/40 (2006.01) C07F 9/42 (2006.01) C07K 16/00 (2006.01) C12N 9/00 (2006.01) C12N 9/14 (2006.01)

Patent

CA 2007816

ABSTRACT OF THE DISCLOSURE A stereoisomeric analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand and the stereochemistry of the nearby atoms is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds stereospecifically to one stereoisomer of the analog-ligand and also to one stereoisomer of the reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand a predetermined site. 0411C, D-186M

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