Benzothiophene, benzofuran and indole-thiazepinones,...

Details Benzothiophene, benzofuran and indole-thiazepinones,... Benzothiophene, benzofuran and indole-thiazepinones,...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2181354

Benzothiophene, benzofuran and indolethiazepinones, ox- azepinones and diazepinones of formula (I) as well as meth- ods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compounds also inhibit the activation of human immun- odeficiency virus (HIV).

L'invention concerne des thiazépinones de benzothiophène, de benzofurane et d'indole, des oxazépinones et des diazépinones de la formule (I) ainsi que leurs procédés de production. Ces composés sont utilisés comme inhibiteurs d'adhérence des leucocytes à l'endothélium vasculaire et, constituent, en tant que tels, des principes thérapeutiques efficaces pour traiter les maladies inflammatoires. Ces composés inhibent également l'activation du virus de l'immunodéficience humaine (VIH).

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