C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/27 (2006.01) A61K 31/4015 (2006.01) A61P 3/00 (2006.01) C07D 401/10 (2006.01)
Patent
CA 2649650
The present invention discloses novel compounds of Formula I: ( I ) possessing 11.beta. -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 .beta. -HSD type 1 activity.
La présente invention concerne de nouveaux composés de formule I : ( I ) possédant une activité antagoniste contre l'enzyme 11.beta. HSD de type 1, ainsi que des procédés de préparation de tels composés. Dans un autre mode de réalisation, l'invention décrit des compositions pharmaceutiques comprenant des composés de la formule I, ainsi que des procédés d'utilisation des composés et des compositions pour le traitement du diabète, de l'hyperglycémie, de l'obésité, de l'hypertension, de l'hyperlipidémie, du syndrome métabolique, des troubles cognitifs et autres états associés à l'activité de l'enzyme 11.beta. HSD de type 1.
Allen John Gordon
Krasutsky Alexei Pavlovych
Wallace Owen Brendan
Xu Yanping
York Jeremy Schulenburg
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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