Low pathogenicity prrs live virus vaccines and methods of...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61K 39/155 (2006.01) C12N 7/02 (2006.01)

Patent

CA 2225388

Live or modified live PRRS vaccines for administration to swine are provided which are of low virulence and confer effective immunity against PRRS. The preferred vaccines include virus isolates having average plaque diameters of less than about 2 mm and low pathogenicity. A preferred vaccine includes a small plaque diameter strain, ATCC Accession No. VR2509. The vaccines of the invention may be administered to breeding females or gilts and to weaned piglets, and is effective to immunize the swine against both the respiratory and reproductive forms of the disease.

L'invention porte sur des vaccins, à administrer au porc, contre le syndrome dysgénésique respiratoire porcin (SDRP), à virus vivant ou à virus vivant modifié, de faible virulence et conférant une forte immunité effective contre le SDRP. Les vaccins préférés comportent des isolats de virus dont le diamètre moyen de plaque est inférieur à 2 mm environ et dont le pouvoir pathogène est faible. Un vaccin préféré comporte une souche à diamètre de plaque réduit, entrée No. ATCC VR2509. Les vaccins selon l'invention, qui peuvent être administrés à des femelles utilisées pour la reproduction ou à de jeunes truies ainsi qu'à des porcelets sevrés, se révèlent efficaces pour immuniser le porc contre les deux formes de la maladie, respiratoire et dysgénésique.

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