C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 31/712 (2006.01) A61P 9/00 (2006.01) C07H 19/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2746003
Oligonucleotide compounds modulate expression and/or function of Vascular Endothelial Growth Factor (VEGF) polynucleotides and encoded products thereof. Methods for treating diseases associated with Vascular Endothelial Growth Factor (VEGF) comprise administering one or more Oligonucleotide compounds designed to inhibit the VEGF natural antisense transcript to patients.
Selon l'invention, des composés oligonucléotidiques modulent l'expression et/ou la fonction de polynucléotides du facteur de croissance de l'endothélium vasculaire (VEGF) et de produits codés de ceux-ci. L'invention porte également sur des procédés de traitement de maladies associées au facteur de croissance de l'endothélium vasculaire (VEGF) qui comprennent l'administration d'un ou plusieurs composés oligonucléotidiques mis au point pour inhiber la transcription antisens naturelle VEGF chez des patients.
Collard Joseph
Khorkova Sherman Olga
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Opko Curna Llc
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