Solution phase biopanning method using engineered decoy...

Details Solution phase biopanning method using engineered decoy... Solution phase biopanning method using engineered decoy...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2564098

The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains the targeted domain or epitope. The invention is based on the use of physical data, which may be combined with derived data, to ascertain that the decoy and the target differ only in the specific functional domain or epitope where the binding will be directed.

L'invention concerne une méthode permettant d'orienter la sélection de molécules thérapeutiques biologiques vers des domaines fonctionnels spécifiques de la molécule biologique cible. La sélection consiste à utiliser des molécules étroitement liées, une des molécules faisant office de leurre et l'autre contenant le domaine ou l'épitope visé. L'invention repose sur l'utilisation de données physiques pouvant être combinées à des données dérivées pour garantir que le leurre et la cible diffèrent uniquement au niveau du domaine fonctionnel ou de l'épitope spécifique concerné.

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