Treatment of autoimmune disease

Details Treatment of autoimmune disease Treatment of autoimmune disease

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065414

Autoimmune diseases are associated with particular immunoglobulin isotypes, particularly the isotypes IgG or IgM, and can be treated by specifically suppressing the production of that immunoglobulin isotype or subtype. Isotypic-specific suppression can be achieved by administering peptides which have an amino acid sequence corresponding to the extracellular segment of the membrane-bound domain (the "migis" segment) of an immunoglobulin of the isotypic class or subclass or an epitope.thereof. Suppression can also be achieved by administering antibodies and related and derivative products specific for the migis segment.

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