Rna interference mediated inhibition of gene expression...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 31/00 (2006.01) C07H 3/02 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2542835

This invention relates to compounds, compositions, and methods useful for modulating gene expression using short interfering nucleic acid (siNA) molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes, such as expressed pseudogenes associated with the maintenance or development of diseases, disorders, traits, and conditions in a subject or organism.

L'invention concerne des composés, des compositions et des procédés servant à moduler l'expression génétique à l'aide de molécules d'acide nucléique d'interférence court (siNA). L'invention concerne en particulier de petites molécules d'acide nucléique telles que des molécules d'acide nucléique d'interférence court (siNA), d'ARN d'interférence court (siRNA), d'ARN double brin (dsRNA), de micro-ARN (miRNA) et d'ARN court en épingle à cheveux (shRNA). L'invention concerne par ailleurs des procédés servant à moduler l'expression de gènes tels que des pseudogènes exprimés, associés à l'entretien ou au développement de maladies, de troubles, de traits psychologiques et d'états pathologiques dans un sujet ou un organisme.

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