Helical polypeptide zalpha29

Details Helical polypeptide zalpha29 Helical polypeptide zalpha29

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2377580

Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least 15 contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:4, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.

Cette invention a trait à de nouveaux polypeptides de cytokine, à des substances et à des techniques permettant de les produire ainsi qu'à des méthodes d'utilisation. Ces polypeptides, qui comprennent au moins 15 restes d'acides aminés contigus appartenant à la SEQ ID N· 2 ou à la SEQ ID N· 4, peuvent être préparés en tant que fusions polypeptidiques, lesquelles comprennent des séquences hétérologues, telles que des marqueurs d'affinité. Les polypeptides et les nucléotides les codant peuvent être utilisés dans une large variété de domaines, thérapeutiques, diagnostiques et de recherche.

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