A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01)
Patent
CA 2376473
Since glucagon-like peptide-1 (GLP-1) is the most potent insulinotropic hormone known and has been shown to stimulate insulin secretion strongly in patients with type II diabetes, this invention uses GLP-1 or its biologically active analogues in .beta.-cell stimulatory tests in order to test .beta.-cell function in a simple way. The test provides information about insulin secretory capacity, is easy and reproducible and has insignificant side effects.
Le peptide-1 apparenté au glucagon (GLP-1) étant la plus puissante hormone insulinotropique connue et possédant un pouvoir avéré de forte stimulation de sécrétion insulinique chez des patients souffrant du diabète non insulino-dépendant, les méthodes de la présente invention mettent en oeuvre GLP-1 ou ses analogues biologiquement actifs dans un essai de stimulation de la cellule bêta visant à déterminer de manière simple la fonction de la cellule bêta. Cet essai fournit des informations sur le pouvoir de sécrétion insulinique, est facile à réaliser et à reproduire, et ses effets secondaires sont négligeables.
Holst J. J.
Vilsboll Tina
Amylin Pharmaceuticals Inc.
Bionebraska Inc.
Ridout & Maybee Llp
LandOfFree
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