Methods for detecting and modulating the sensitivity of...

Details Methods for detecting and modulating the sensitivity of... Methods for detecting and modulating the sensitivity of...

A - Human Necessities

61

K

A61K 31/7088 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2679393

A method of screening a tumour cell for resistance to a tubulin-binding agent, the method comprising detecting the expression of any one or more of class II, class III and class IVb .beta.-tubulin by the tumour cell, wherein the expression of any one or more of class II, class III and class IVb .beta.-tubulin indicates that the tumour cell has resistance or potential resistance to the tubulin-binding agent.

L'invention concerne un procédé de criblage d'une cellule tumorale pour une résistance à un agent de liaison à la tubuline. Ce procédé comprend la détection de l'expression de la .beta.-tubuline d'une ou plusieurs classes parmi les classes II, III et IVb par la cellule tumorale, l'expression de la .beta.-tubuline d'une ou plusieurs classes parmi les classes II, III et IVb indiquant que la cellule tumorale a une résistance ou une résistance potentielle à l'agent de liaison à la tubuline.

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