C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/66 (2006.01) A61K 31/428 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 25/28 (2006.01) C07D 277/64 (2006.01) G01N 33/534 (2006.01)
Patent
CA 2419420
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, <i>in vivo</i> imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
La présente invention concerne de nouveaux dérivés de thioflavine, des méthodes d'utilisation desdits dérivés (par exemple par imagerie <i>in vivo</i> de patients présentant des plaques neuritiques) dans des compositions pharmaceutiques renfermant lesdits dérivés de thioflavine, et une méthode de synthèse des composés. Ceux-ci sont particulièrement utiles dans le diagnostic et le traitement de patients souffrant de maladies, dans lesquelles l'accumulation de plaques neuritiques est courante. Les troubles ou les maladies comprennent la maladie d'Alzheimer, la maladie familiale d'Alzheimer, le syndrome de Down et les homozygotes de l'allèle E4 de l'apolipoprotéine, mais ne se limitent pas à ceux-ci.
Klunk William E.
Mathis Chester A. Jr.
Wang Yanming
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Pittsburgh - Of The Commonwealth System Of Higher
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