Method for antibody targeting of diagnostic or therapeutic...

Details Method for antibody targeting of diagnostic or therapeutic... Method for antibody targeting of diagnostic or therapeutic...

A - Human Necessities

61

K

167/139, 167/45

A61K 39/44 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2005162

ABSTRACT OF THE DISCLOSURE The targeting capability of an antibody is enhanced using an antibody-enzyme conjugate and a separate soluble substrate-agent conjugate, wherein the targeted enzyme catalyzes the conversion of a soluble substrate, bearing at least one therapeutic or diagnostic agent, to a product comprising the agent, which accumulates at the target site for effective treatment or diagnosis. This method is useful for targeting any type of agent to a site to which an antibody can selectively bind, including use for imaging, e.g., tumors, infectious lesions, fibrin clots, myocardial infarctions, non-cancerous cells, damaged normal cells, atherosclerotic plaque, lymphocyte autoreactive clones, and for therapy, e.g., with drugs, toxins, immune modulators, radioisotopes or antibiotics.

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