Combinations of aldose reductase inhibitors and selective...

Details Combinations of aldose reductase inhibitors and selective... Combinations of aldose reductase inhibitors and selective...

A - Human Necessities

61

K

A61K 31/404 (2006.01) A61K 31/18 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 31/4188 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/47 (2006.01) A61K 31/4725 (2006.01) A61K 31/4747 (2006.01) A61K 31/495 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 4

Patent

CA 2313063

This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and a selective COX-2 inhibitor,a prodrug thereof or a pharmaceutically acceptable salt of said selective COX-2 inhibitor or said prodrug. This invention further relates to methods of using those pharmaceutical compositions for the treatment of diabetic complications such as diabetic neuropathy, diabetic nephropathy, diabetic retinopathy and diabetic cardiomyopathy.

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