C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/56 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) A61K 31/44 (2006.01) C07C 237/22 (2006.01) C07D 207/337 (2006.01) C07D 209/20 (2006.01) C07D 209/44 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/50 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/61 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2224198
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi- drug resistant cancer therapy.
La présente invention concerne les composés qui peuvent maintenir, améliorer ou bien rétablir la sensibilité des cellules aux agents thérapeutiques ou prophylactiques. Elle concerne également les compositions pharmaceutiques qui comprennent ces composés. Les composés et les compositions pharmaceutiques décrits dans l'invention sont particulièrement bien adaptés au traitement des cellules qui résistent à plusieurs médicaments, à la prévention du développement de la résistance à plusieurs médicaments et, enfin, au traitement thérapeutique pour les cas de cancer résistant à plusieurs médicaments.
Harding Matthew W.
Zelle Robert E.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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