Soft-gelatin capsule formulation

Details Soft-gelatin capsule formulation Soft-gelatin capsule formulation

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 31/5575 (2006.01)

Patent

CA 2637274

The present invention discloses a soft gelatin capsule formulation of a 15- keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto- prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.

L'invention concerne une formulation de capsule gélatineuse molle contenant un composé de 15-céto-prostaglandine, comprenant une enveloppe de capsule gélatineuse molle contenant de la gélatine et un alcool de sucre en tant que plastifiant, et un mélange contenant un composé de 15-céto-prostaglandine et un excipient acceptable d'un point de vue pharmaceutique intégré dans l'enveloppe. L'enrobage du composé de 15-céto-prostaglandine dans l'enveloppe de capsule gélatineuse molle permet d'améliorer de manière significative la stabilité du composé.

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