C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441416
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diabetes mellitus and/or conditions related to diabetes. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of, polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the jpolypeptides of the present invention.
La présente invention a trait à des polypeptides humains sécrétés, et des molécules isolées d'acide nucléique codant pour lesdits peptides, utiles pour le diagnostic et le traitement du diabète sucré et/ou des conditions liées au diabète. L'invention concerne également des anticorps de liaison à de tels polypeptides. L'invention concerne en outre des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse pour la production desdits polynucléotides, polypeptides, et/ou anticorps. L'invention concerne aussi des procédés de criblage permettant l'identification d'agonistes et d'antagonistes des polynucléotides et polypeptides de l'invention. Enfin, l'invention concerne des procédés et des compositions permettant l'inhibition ou l'amélioration de la production et de la fonction desdits polypeptides.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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