Diagnostic marker and platform for drug design in myocardial...

Details Diagnostic marker and platform for drug design in myocardial... Diagnostic marker and platform for drug design in myocardial...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2675606

Methods for determining the susceptibility of an individual to a heart condition, post myocardial infarction, comprising detecting the presence of an amino acid change in the sequence of the hemopexin domain of MMP -9 (Matrix Metalloproteinase 9), the presence of an amino acid change in said domain being indicative of susceptibility to said heart condition, post myocardial infarction is described, together with methods for drug design.

La présente invention concerne des procédés destinés à déterminer la susceptibilité d'un individu à souffrir d'un problème cardiaque, l'infarctus post-myocardique. Lesdits procédés comprennent la détection de la présence d'un changement d'acide aminé dans la séquence du domaine de l'hémopexine de MMP-9 (métalloprotéinase matricielle 9); ladite présence d'un changement d'acide aminé dans ledit domaine indique une susceptibilité de souffrir dudit problème cardiaque, c'est-à-dire de l'infarctus post-myocardique. L'invention concerne également des procédés de conception de médicament.

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