Measuring nitric oxide in blood gases and treatments based...

Details Measuring nitric oxide in blood gases and treatments based... Measuring nitric oxide in blood gases and treatments based...

G - Physics

01

N

G01N 33/48 (2006.01) A61K 33/00 (2006.01) A61M 1/02 (2006.01) G01N 33/49 (2006.01) G01N 33/497 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2487719

Nitric oxide is measured in blood as a marker of tissue blood flow and oxygenation. Where nitric oxide is measured to be below physiological or to be below average, in a patient having a disease associated with oxygen delivery deficiency, nitric oxide is infused alone or with nitrite. Where nitric oxide is measured to be normal, nitrite is infused. The storage time of whole blood or red blood cells is increased and the vasodilator response of outdated or NO depleted whole blood and red blood cells are increased by treatment with nitric oxide and/or nitrite. A patient in need of a transfusion is transfused with whole blood or red blood cells treated to increase vasodilator response therein.

Selon l'invention, le monoxyde d'azote est mesuré dans le sang en tant que marqueur du débit sanguin et de l'oxygénation dans un tissu. Lorsque le monoxyde d'azote est mesuré en-dessous d'une norme physiologique ou d'une moyenne chez un patient atteint d'une maladie associée à une déficience d'oxygène, le monoxyde d'azote est infusé seul ou avec du nitrite. Lorsque le monoxyde d'azote mesuré est normal, le nitrite est infusé. Le temps de conservation du sang entier ou des hématies est accru et la réponse de vasodilatation du sang entier ou des hématies périmés ou dépourvus de NO est augmentée par traitement au monoxyde d'azote et/ou au nitrite. Un patient nécessitant une transfusion est transfusé avec du sang entier ou des hématies traités dans le but d'en augmenter la réponse de vasodilatation.

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