C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 167/238
C07D 231/12 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) C07D 231/22 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2012565
ABSTRACT OF THE DISCLOSURE N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole- 1-(branched)alkanamides and pyrazole-1-alkanamines of the formula below useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine. (I) Image (wherein: R1 is hydrogen or lower-alkyl; R2 and R3 are independently hydrogen, hydroxy, lower- alkyl, lower-alkoxy, or halo; R4 and R5 are independently hydrogen or lower-alkyl, or R4 and R5 together form a straight or branched alkylene chain of four to six carbon atoms; R6 and R7 are independently hydrogen or straight-chain lower alkyl; r is zero or one; q is one when r is zero; and q is zero when r is one and in that case at least one of R6 and R7 is not hydrogen; and A is CH2CH(OH)CH2 or (CH2)n [wherein n is an integer from two to eight]) or an acid addition salt or solvate thereof.
Bailey Denis M.
Powles Ronald G.
Bailey Denis M.
Fetherstonhaugh & Co.
Powles Ronald G.
Sterling Drug Inc.
LandOfFree
1h-pyrazole-1alkanamines and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1h-pyrazole-1alkanamines and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1h-pyrazole-1alkanamines and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2068045