Substituted urea neuropeptide y y5 receptor antagonists

Details Substituted urea neuropeptide y y5 receptor antagonists Substituted urea neuropeptide y y5 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/96 (2006.01) A61K 31/4468 (2006.01) A61K 31/4545 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 211/58 (2006.01)

Patent

CA 2454830

The present invention discloses compounds of formula (I) which are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

L'invention concerne des composés représentés par la formule (I), ces composés étant de nouveaux antagonistes du récepteur Y5 du neuropeptide Y (NPY) ainsi que des procédés permettant de préparer ces composés. L'invention concerne également des compositions pharmaceutiques comprenant lesdits antagonistes du récepteur NPY Y5 ainsi que des procédés utilisant ces antagonistes pour traiter l'obésité, les troubles du métabolisme, les troubles de l'alimentation tels que l'hyperphagie, et les diabètes.

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